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| MUSCLE RELAXANTS |
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| PAIN RELIEF |
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| ANTI-DEPRESSANTS |
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| MEN'S HEALTH |
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TRAMADOL®
Tramadol® (generic for Ultram®) is a prescription
medication used for the management of moderate to moderately severe
pain. Tramadol® has been prescribed to
more than 55 million patients worldwide; Ultram® has been prescribed
to more than 21 million patients in the U.S. |
Buy Tramadol®
Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
Uses
Tramadol is used for pain relief.
How to Use
Take this medication of tramadol by mouth as prescribed. It is usually
taken every 4 to 6 hours as needed. Use this tramadol medication exactly
as prescribed. Do not increase your dose, use it more frequently or use
it for a longer period of time than prescribed because this drug can be
habit-forming. Also, if used for an extended period of time, do not suddenly
stop using this drug without your doctor's approval. When used for extended
periods, this medication may not work as well and may require different
dosing. Consult your doctor if the medication stops working well.
Side Effects
This tramadol medication may cause dizziness, weakness, incoordination,
nausea or vomiting, stomach upset, constipation, headache, drowsiness,
anxiety, irritability, dry mouth, or increased sweating. If any of these
effects persist or worsen, inform your doctor. Notify your doctor if you
develop any of these serious effects while taking this tramadol medication:
chest pain, rapid heart rate, skin rash or itching, mental confusion,
disorientation, seizures, tingling of the hands or feet, trouble breathing.
In the unlikely event you have an allergic reaction to this drug (tramadol)
, seek immediate medical attention. Symptoms of an allergic reaction include:
rash, itching, swelling, dizziness, breathing trouble. If you notice other
effects not listed above, contact your doctor or pharmacist.
Precautions
Tell your doctor your medical history, especially of: kidney disease,
liver disease, seizure disorder, lung disease, history of drug or alcohol
dependency, any allergies you may have. Limit alcohol as it may add to
the dizziness or drowsiness effects caused by the medication. Because
this drug may make you dizzy/drowsy, use caution performing tasks requiring
alertness such as driving. This tramadol medication should be
used only when clearly needed during pregnancy. Discuss the risks and
benefits with your doctor. Tramadol is excreted into breast milk. Because
the effects on a nursing infant are not known, consult your doctor before
breast- feeding.
Drug Interactions
Tell your doctor of all prescription and nonprescription medications you may use, especially of: carbamazepine, narcotic pain relievers (e.g., codeine), drugs used to aid sleep, antidepressants (e.g., SSRI-types such as fluoxetine or fluvoxamine), MAO inhibitors (e.g., furazolidone, linezolid, phenelzine, procarbazine, selegiline, tranylcypromine), psychiatric medicine (e.g., nefazodone), "triptan"-type drugs, anti-anxiety drugs (e.g., diazepam), sibutramine. Also, report use of certain antihistamines (e.g., diphenhydramine) which are also present in many cough-and-cold products. Do not start or stop any medicine without doctor or pharmacist approval.
Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include cold and clammy skin, low body temperature, slowed breathing, slowed heartbeat, drowsiness, dizziness, lightheadedness, deep sleep, loss of consciousness, or seizures.
Notes
Do not share this medication ( tramadol ) with others.
Missed Dose
If you miss a dose, take it as soon as remembered; do not take tramadol
if it is near the time for the next dose, instead, skip the missed dose
and resume your usual dosing schedule. Do not double the dose to catch
up.
Storage
Store tramadol at room temperature between 59 and 86 degrees F (15 to
30 degrees C) away from heat and light. Do not store in the bathroom.
Keep tramadol and all medications out of the reach of children.
Mechanism of action
The mechanism of action of tramadol
has yet to be fully elucidated, but it is believed to work through modulation
of the GABAergic, noradrenergic and serotonergic systems. The contribution
of non-opioid activity is demonstrated by the analgesic effects of tramadol
not being fully antagonised by the µ-opioid receptor antagonist
naloxone.
Tramadol is marketed as a racemic mixture with a weak affinity for the
µ-opioid receptor (approximately 1/6000th that of morphine). The
(+)-enantiomer is approximately four times more potent than the (-)-enantiomer
in terms of µ-opioid receptor affinity and 5-HT reuptake, whereas
the (-)-enantiomer is responsible for noradrenaline reuptake effects (Shipton,
2000). These actions appear to produce a synergistic analgesic effect,
with (+)-tramadol exhibiting 10-fold higher analgesic activity than (-)-tramadol
(Goeringer et al., 1997).
The serotonergic modulating properties of tramadol mean that it has the
potential to interact with other serotonergic agents. There is an increased
risk of serotonin syndrome when tramadol is taken in combination with
serotonin reuptake inhibitors (e.g. SSRIs), since these agents not only
potentiate the effect of 5-HT but also inhibit tramadol's metabolism.
It is suggested that tramadol could be effective for alleviating symptoms
of depression and anxiety because of its action on GABAergic, noradrenergic
and serotonergic systems. However, use of the drug for treatment of such
disorders by a health professional is unlikely.
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